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In a perfect world (such as between identical twins), the HLA typing is a 10/10 or 12/12 match.
In most transplants:
The better the match: The less likely the recipient’s immune system will recognize the organ as “foreign,” leading to a longer lasting transplant and potentially lower doses of anti rejection medications.
A “mismatch”: If the donor has an HLA type (e.g., HLA A2) that the recipient’s immune system has already developed antibodies against (high MFI), the transplant is considered high risk.
Modern medicine has become so good at managing mismatches with drugs (like Tacrolimus and Mycophenolate) that a “mismatch” is no longer a deal breaker. As long as the Virtual Crossmatch is negative—meaning the recipient does not have pre existing antibodies against those specific mismatches—the transplant can still be very successful.
Bu sayfanın altına da CTA ekleyebiliriz: “Contact us to discuss your transplant compatibility”
